Tuesday, December 2, 2008

Andrographis paniculata (BURM.F.)WALLICH EX NEES


Family : Acanthaceae

Synonym(s) : Andrographis subspathulata C.B. Clarke, Justica paniculata Burm. f.

English Name : The Creat

Origin : India and Srilanka

Description

It is an erect annual herb. Stem is dark green, quadrangular with longitudinal furrows and wings on the angles of the younger parts and slightly enlarged at the nodes. The leaves are glabrous, dark green, arranged opposite decussate, lanceolate and pinnate. The flowers are small, in lax spreading axillary and terminal racemes or panicles. The capsules are linear-oblong and acute at both ends. The seeds are numerous, sub-quadrate and yellowish brown in colour.

Habitat

Forests and wetlands of Madhya and Uttar Pradesh and southern India; also in Sri Lanka, Java, the West Indies and Mauritius.

Parts Used : Plant, leaf and shoot

Herb Effects

Astringent, anodyne, tonic, alexipharmic, tonic, febrifuge, stomachic, cholagogue, stimulant, aperient, antityphoid, antifungal, protects liver, antidiabetic and cholinergic (plant); lowers blood pressure (leaf); antibacterial (shoot).

Active Ingredients

Andrographolide, neoandrographolide (plant); homoandrographolide, andrographosterol and andrographone (leaf).

Medicinal Use

Fever, stomach problems, diarrhea, dysentery and indigestion (plant decoction); auto-immune disorders, HIV/AIDS, heart disease, insect bites, cholera, diabetes, malaria, tuberculosis, rabies and snakebite.

Dosage

400 mg, 3 times a day.

Contraindication

Although andrographis has been found to be safe in humans, animal studies suggest it may impair fertility.

Reference

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2. Bentley and Trimen, Antimalarial activity of Andrographis paniculata (Kalmegh) against Plasmodim berghei NK 65 in Mastomys natalensis. Int. J. Pharmacog. 30(4): 263-74.

3. Caceres D.D., J.L. Hancke, R.A. Burgos, and G.K. Wikman. 1997. Prevention of common colds with Andrographis paniculata dried extract: A pilot double-blind trial. Phytomedicine. 4(2): 101-4.

4. Chandel et al., Biodiversity in Medicinal and Aromatic Plants in India.

5. Chem Weiming and Liang Xiaotion. Deoxyandrographolide 19ß-D-glucoside from the leaves of A. paniculata, Planta Medica 1982; 15: 245-246.

6. Chturvedi, G.N., G.S. Tomar, S.K. Tiwari, and K.P. Singh. 1983. Clinical studies on Kalmegh (Andrographis paniculata Nees) in infective hepatitis. Journal of International Institute of Ayurveda 2:208-11.

7. Coon JT, Ernst E. Andrographis paniculata in the treatment of upper respiratory tract nfections: a systematic review of safety and efficacy. Planta Medica 2004 Apr;70(4):293-8.

8. Deng, W.L. 1978. Outline of current clinical and pharmacological research on Andrographis paniculata in China. Newsletters of Chinese Herbal Med. 10:27-31.

9. Deng, W.L. 1978. Preliminary studies on the pharmacology of the Andrographis product dihydroandrographolide sodium succinate. Newsletters of Chinese Herbal Med. 8:26-28.

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12. Guo, S.Y., D.Z. Li, W.S. Li, A.H. Fu, and L.F. Zhang. 1988. Study of the toxicity of andrographolide in rabbits. J. Beijing Med. Univ. 5:422-28.

13. Gupta, S., M. A. Choudhry, J.N.S. Yadava, V. Srivastava, and J.S. Tandon. 1990. Antidiarrheal activity of diterpenes of Andrographis paniculata (Kalmegh) against Escherichia coli enterotoxin in in vivo models. Int. J. Crude Drug Res. 28; 4:273-83.

14. Huang, L.Y. 1987. The effects of andrographolides on experimental blood deficiency of cardiac muscle. Chinese Herbal Med. 18(7): 26-28.

15. Huang, Q.Z. 1974. Treating herpes using Andrographis paniculata products. Guangxi Health 5:43.

16. Hueng, S.J. 1991. Treating anal tumor by washing using Andrographis paniculata extractions plus vinegar. Chinese J. Anal. Intest. Dis. 11(2):40.

17. Jean Barilla, M.S., 1999. Andrographis paniculata: Can herbs fight common ailments, cancer, and chronic viral infections?, A Keats Good Health Guide, p. 17-20.

18. Johnson T. CRC Ethnobotany Desk Reference (www.herbweb.com/herbage).

19. Kapil, A., I.B. Koul, S.K. Banerjee, and B.D. Gupta. 1993. Antihepatotoxic effects of major diterpenoid constituents of Andrographis paniculata. Biochemical Pharmacology 46(1):182-85.

20. Lingtang Town Hospital of Gaoyou County. 1975. Treating vaginitis using Andrographis paniculata. Jiangshu Med. 6:45-46.

21. Madav. H.C., T. Tripathi, and S.K. Mishra. 1995. Analgesic, antipyretic, and antiulcerogenic effects of andrographolide. Indian J. Pharm. Sci. 57(3):121-25.

22. Matsuda, T., M. Kuroyanagi, S. Sugiyama, K. Umehara, A. Ueno, and K. Nishi. 1994. Cell differentiation-inducing diterpenes from Andrographis paniculata Nees. Chem. Pharm. Bull (Tokyo) 42(6):1216-25.

23. Misra, P., N.L. Pal, P.Y. Guru, J.C. Katiyar, V. Srivastava, J.S. Tandon. 1992.

24. Puri, A., R. Saxena, R.P. Saxena, and K.C. Saxena. 1993. Immunostimulant agents from Andrographis paniculata. J. Natural Products 56(7):995-99.

25. Qi, w.C. 1965. Investigations of forty-five cases of infant cutaneous gangrene treated by Yi-Jian-Xi cream. Traditional Chinese Med. in Fujian 4:32.

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27. Shanghai City Andrographis Research Group, 1976. A study on water-soluble andrographolide. Newsletters of Chinese Herbal Med. 3:10-18.

28. Sharma, A., L. Krishan, and S.S. Handa. 1992. Standardization of the Indian crude drug Kalmegh by high pressure liquid chromatographic determination of andrographolide. Phytochemical analysis 3:129-31

29. Shukla, B., P.K.S. Visen, G.K. Patnaik, and B.N. Dhawan. 1992. Choleretic effect of andrographolide in rats and guinea pigs. Planta Med. 58:146-48.

30. Siripong, P., B. Kongkathip, K. Preechanukool, P. Picha, K. Tunsuwan, and W.C. Taylor. 1992. Cytotoxic diterpenoid constituents from Andrographis paniculata, Nees leaves, J. Sci. Soc. Thailand 18(4):187-94.

31. Talukdar, P.B., and S. Banerjee. 1968. Studies on the stability of andrographolide. Indian J.Chem. 6:252-54.

32. Wang, D., and H. Zhao. 1993. Experimental studies on prevention of atherosclerotic arterial stenosis and restenosis after angioplasty with Andrographis paniculata Nees and fish oil. J. of Tongji Medical University 13(4):193-98.

33. Zhao, H., and W. Fang. 1990. Protective effects of Andrographis paniculata Nees on post-infarction myocardium in experimental dogs. J. of Tongji Medical University 10(4):212-17.

34. Zheng, Z.Y. 1982. Pharmacokinetic studies on 3H-andrographolide. Chinese Herbal Med. 13(9):33-36.

35. Zoha, M.S., A.H. Hussain, and S.A. Choudhury. 1989. Antifertility effects of Andrographis paniculata in mice. Bangladesh Med. Res. Council Bull. 15:34-37.

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