Tuesday, December 2, 2008

Antidiabetic and antioxidant potential of Phyllanthus fraternus in alloxan induced diabetic animals

Phcog Mag. Vol 4, Issue 14, Apr-Jun, 2008


Implication of oxidative stress in diabetes due to oxygen free-radical generation and alteration in antioxidant enzymes is now well documented. Phyllanthus fraternus is a widely used folklore plant in several disorders due to its excellent properties and potent phytoconstituents. In this study, antidiabetic and antioxidant potential of petroleum ether, ethanolic and aqueous extracts of the whole plant of Phyllanthus fraternus was estimated in alloxan-induced diabetic albino rats. In a 21 days study, animals were divided into six groups (A-F) of six rats each. Group A served as normal control, group B as diabetic control, Groups C, D & E were administered with three different plant extracts (0.5g /kg), and group F was treated with standard drug tolbutamide (0.2g/kg). Administration of Phyllanthus fraternus extracts has remarkably improved the elevated levels of blood glucose. Ethanolic extract has reduced the blood sugar levels in a significant (p<0.001)>
KEYWORDS : Phyllanthus fraternus, Antidiabetic, Antioxidant activity.


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